You're talking about young Nicolas Depoortère who won his first cap yesterday, and I think you're right that his preferred position is 13 where he was when France U20 won the World Cup last year, but Galthié will probably pick him again in Lyon against England.
Thomas Ramos' tackling can be like the revolving door and he could be replaced by either Antoine Hastoy (La Rochelle) or Antoine Gibert (Racing, with club scrum half Nolann Le Garrec), or put Ramos back to fullback, which'd be tough on Léo Barré as he had a more than satisfactory first cap.
Personally, I'd love to see Gibert and Le Garrec at half back with Ramos maybe on the bench, but Galthié will probably keep Ramos at 10.
There's been one change in Galthié's squad of 34 and that's the call up of Munster centre Antoine Frisch in the the place of Pierre-Louis Barassi.
It's extraordinary, but Frisch has never played in the Top14, and despite being in the Stade Français development squad he wasn't retained and eventually went to Bristol in 2021/22, where he played 13 matches before heading for Munster.